Endocrine Abstracts

PreproTRH (178–199), a 22-aminoacid cleavage product of the TRH prohormone, has been postulated to act as an ACTH-releasing inhibitor. Indeed, in vitro evidence indicates that this peptide may inhibit basal and stimulated ACTH secretion in rodent anterior pituitary primary cultures and cell lines (Redei 1995, Revskoy 2001), although not all studies concur (Nicholson 1996). Aim of the present study was to test the effect of preproTRH(178–199) in human tumoral c...